Table 2.
The GO/KEGG Analysis of TPM2 in Breast Cancer
| ONTOLOGY | ID | Description | GeneRatio | p.Adjust | Zscore | Count | Geneid |
|---|---|---|---|---|---|---|---|
| BP | GO:0043062 | Extracellular structure organization | 72/987 | 6.1757E-24 | 7.54247233 | 72 | COL11A2/COL9A3/KLK5/C6orf15/HAS1/COL17A1/COMP/EMILIN1/GFAP/ANGPTL7/ADAMTS16/MYH11/PTX3/MMP23B/KLK4/ELN/LOXL4/COL1A1/COL8A2/COL16A1/COL9A1/COL11A1/AEBP1/CCN1/MMP14/COL5A3/COL1A2/FOXC2/COL5A1/MMP11/CCN2/ADAMTS14/MMP20/MMP2/MMP10/DPT/COL10A1/GAS6/FOXF2/COL3A1/FBLN2/ZNF469/SFRP2/MMP28/EFEMP2/LOXL2/CTSK/MMP13/MIA/MMP27/MFAP4/COL22A1/TPSAB1/BMP1/COL18A1/COL8A1/KLK7/OLFML2B/COL5A2/LOXL1/MMP7/CTSG/PDPN/ADAMTS7/BMP2/TLL2/ADAMTS2/LAMB3/ADAMTS19/TEX14/PRSS1/MMP26 |
| BP | GO:0030198 | Extracellular matrix organization | 71/987 | 1.4617E-23 | 7.71408078 | 71 | COL11A2/COL9A3/KLK5/C6orf15/HAS1/COL17A1/COMP/EMILIN1/GFAP/ANGPTL7/ADAMTS16/MYH11/PTX3/MMP23B/KLK4/ELN/LOXL4/COL1A1/COL8A2/COL16A1/COL9A1/COL11A1/AEBP1/CCN1/MMP14/COL5A3/COL1A2/FOXC2/COL5A1/MMP11/CCN2/ADAMTS14/MMP20/MMP2/MMP10/DPT/COL10A1/GAS6/FOXF2/COL3A1/FBLN2/ZNF469/SFRP2/MMP28/EFEMP2/LOXL2/CTSK/MMP13/MIA/MMP27/MFAP4/COL22A1/TPSAB1/BMP1/COL18A1/COL8A1/KLK7/OLFML2B/COL5A2/LOXL1/MMP7/CTSG/PDPN/ADAMTS7/BMP2/TLL2/ADAMTS2/LAMB3/ADAMTS19/PRSS1/MMP26 |
| BP | GO:0045229 | External encapsulating structure organization | 71/987 | 1.836E-23 | 7.71408078 | 71 | COL11A2/COL9A3/KLK5/C6orf15/HAS1/COL17A1/COMP/EMILIN1/GFAP/ANGPTL7/ADAMTS16/MYH11/PTX3/MMP23B/KLK4/ELN/LOXL4/COL1A1/COL8A2/COL16A1/COL9A1/COL11A1/AEBP1/CCN1/MMP14/COL5A3/COL1A2/FOXC2/COL5A1/MMP11/CCN2/ADAMTS14/MMP20/MMP2/MMP10/DPT/COL10A1/GAS6/FOXF2/COL3A1/FBLN2/ZNF469/SFRP2/MMP28/EFEMP2/LOXL2/CTSK/MMP13/MIA/MMP27/MFAP4/COL22A1/TPSAB1/BMP1/COL18A1/COL8A1/KLK7/OLFML2B/COL5A2/LOXL1/MMP7/CTSG/PDPN/ADAMTS7/BMP2/TLL2/ADAMTS2/LAMB3/ADAMTS19/PRSS1/MMP26 |
| BP | GO:0030199 | Collagen fibril organization | 24/987 | 2.3569E-12 | 4.89897949 | 24 | COL11A2/COMP/EMILIN1/LOXL4/COL1A1/COL11A1/AEBP1/COL5A3/COL1A2/FOXC2/COL5A1/MMP11/ADAMTS14/DPT/COL3A1/SFRP2/EFEMP2/LOXL2/BMP1/COL5A2/LOXL1/ADAMTS7/TLL2/ADAMTS2 |
| BP | GO:1901890 | Positive regulation of cell junction assembly | 16/987 | 0.01060123 | 1.5 | 16 | CLDN19/OXT/SYNDIG1/CLDN5/COL16A1/THBS2/THY1/MYOC/SLITRK3/ADGRB1/ST8SIA2/NRXN1/LRRTM3/ASIC2/SLITRK1/LRTM2 |
| BP | GO:0031424 | Keratinization | 14/987 | 0.01175013 | 3.2071349 | 14 | LCE1A/KRT1/KRT81/KLK5/KRT83/LORICRIN/KRT17/KRT86/KRT75/LCE1C/KRT85/KRT71/LCE3A/KRT4 |
| BP | GO:0034329 | Cell junction assembly | 40/987 | 0.01571355 | 1.26491106 | 40 | CLDN19/OXT/COL17A1/NPAS4/SYNDIG1/CLDN5/NR1H4/POU4F1/COL16A1/MMP14/NRG1/DNER/FAM107A/THBS2/CDH22/IGFN1/GAP43/THY1/NRXN2/MYOC/CLDN11/SLITRK3/ADGRB1/ST8SIA2/NRXN1/LHFPL4/ROBO2/CDHR3/PARD6B/GPM6A/GABRA1/SLIT1/LRRTM3/GHSR/ASIC2/SLITRK1/CHRNB2/CDH7/GABRG2/LRTM2 |
| BP | GO:0042391 | Regulation of membrane potential | 40/987 | 0.01818229 | −1.5811388 | 40 | CLDN19/SCN2B/NPAS4/DRD4/GLRA3/KCNH5/FZD9/CACNA1G/KCNK17/FHL1/KCNA1/GABRA4/MYOC/DCN/GRIN2A/NRXN1/GRIN2C/HCN2/CHRNA2/KCNH6/CNR1/RIMS2/GLRA1/NTSR2/GABRA1/CACNB2/ASIC2/KCNJ3/KCNC2/KCNK3/TRPC5/SLC8A2/CHRNB2/INSYN2A/GABRG2/CHRNA9/UCN3/KCNC1/GRIA1/SEZ6 |
| BP | GO:0098743 | Cell aggregation | 6/987 | 0.03507492 | 0 | 6 | COL11A1/CCN2/BMP1/BPIFA1/BMPR1B/FGF4 |
| BP | GO:1902742 | Apoptotic process involved in development | 8/987 | 0.04067603 | 0.70710678 | 8 | CRYAB/CCN1/FOXC2/HAND2/SIX3/ROBO2/FGF4/XKR7 |
| CC | GO:0034702 | Ion channel complex | 34/1042 | 0.00048078 | −1.0289915 | 34 | KCNMB1/TTYH1/SCN2B/GLRA3/DPP6/CACNA1G/GRIA4/LRRC38/KCNA1/GABRA4/KCNG1/VWC2/CACNG7/GRIN2A/GRIN2C/HCN2/CHRNA2/CNGB3/GLRA1/OLFM3/GABRA1/CACNB2/GRIA2/KCNG4/KCNJ3/KCNC2/UNC80/TRPC5/VWC2L/CHRNB2/GABRG2/CHRNA9/KCNC1/GRIA1 |
| CC | GO:0001725 | Stress fiber | 9/1042 | 0.06399549 | 3 | 9 | ACTA1/MYH7/XIRP2/MYL9/ACTA2/PDLIM7/MYLK/FAM107A/PDLIM4 |
| MF | GO:0005200 | Structural constituent of cytoskeleton | 12/929 | 0.0574778 | 1.73205081 | 12 | KRT14/ACTA1/DES/LORICRIN/KRT9/GFAP/NEFM/SYNM/NEFL/POTEKP/ANK1/ACTL6B |
| KEGG | Hsa04512 | ECM-receptor interaction | 12/381 | 0.02720231 | 2.30940108 | 12 | COL9A3/COMP/COL6A2/COL6A1/COL1A1/COL9A1/COL1A2/ITGA11/THBS2/LAMB3/DSPP/VTN |
| KEGG | Hsa04510 | Focal adhesion | 20/381 | 0.03200542 | 4.02492236 | 20 | MYL7/COL9A3/COMP/SHC4/COL6A2/FLNC/MYL9/MYL2/COL6A1/COL1A1/COL9A1/COL1A2/MYLK/ITGA11/THBS2/PAK5/LAMB3/PGF/VEGFD/VTN |
| KEGG | Hsa04024 | cAMP signaling pathway | 21/381 | 0.03451233 | −0.6546537 | 21 | OXT/MYL9/POMC/GABBR2/GRIA4/HTR1A/CALML3/CAMK2A/GRIN2A/GRIN2C/NPY1R/HCN2/ADCY1/CNGB3/SST/GHSR/GRIA2/CRH/HTR1E/CGA/GRIA1 |
| KEGG | Hsa04915 | Estrogen signaling pathway | 15/381 | 0.03458971 | 1.29099445 | 15 | KRT14/KRT13/KRT9/KRT34/KRT17/SHC4/POMC/GABBR2/MMP2/CALML3/ESR1/ADCY1/GNAO1/KRT28/KCNJ3 |
| KEGG | Hsa04310 | Wnt signaling pathway | 16/381 | 0.08130232 | 4 | 16 | WIF1/SFRP5/LGR5/FZD9/APCDD1L/FOSL1/NKD2/NOTUM/SFRP2/SFRP4/SERPINF1/LGR6/WNT6/MMP7/CAMK2A/WNT5B |
Abbreviations: BP, Biological Process; CC, Cellular Component; MF, Molecular Function; KEGG, Kyoto Encyclopedia of Genes and Genomes.