Table 4.
Adjusted Association (HR, 95% CI) Between Self-Reported Extent Bothered by Itchy Skin and Outcomes, Impact of Progressive Adjustment
| Self-Reported Extent Bothered by Itchy Skin |
|||||
|---|---|---|---|---|---|
| 1: Not At All Bothered | 2: Somewhat Bothered | 3: Moderately Bothered | 4: Very Much Bothered | 5: Extremely Bothered | |
| KRT initiation | |||||
| Model 1 | 1 (reference) | 1.03 (0.88-1.21) | 1.17 (0.98-1.39) | 1.09 (0.80-1.48) | 1.16 (0.76-1.79) |
| Model 2 | 1 (reference) | 1.04 (0.89-1.22) | 1.15 (0.96-1.37) | 1.09 (0.80-1.47) | 1.18 (0.78-1.80) |
| Model 3 | 1 (reference) | 1.08 (0.91-1.27) | 1.09 (0.91-1.32) | 1.15 (0.85-1.56) | 1.17 (0.76-1.80) |
| CKD progression | |||||
| Model 1 | 1 (reference) | 0.96 (0.83-1.10) | 1.10 (0.91-1.34) | 0.93 (0.70-1.22) | 0.95 (0.69-1.32) |
| Model 2 | 1 (reference) | 0.96 (0.83-1.11) | 1.09 (0.90-1.33) | 0.91 (0.69-1.20) | 0.96 (0.70-1.31) |
| Model 3 | 1 (reference) | 0.98 (0.85-1.14) | 1.03 (0.85-1.25) | 0.94 (0.71-1.23) | 0.93 (0.66-1.31) |
| All-cause mortality | |||||
| Model 1 | 1 (reference) | 0.94 (0.75-1.17) | 1.15 (0.88-1.50) | 1.08 (0.77-1.53) | 1.74 (1.11-2.73) |
| Model 2 | 1 (reference) | 0.96 (0.77-1.19) | 1.15 (0.88-1.51) | 1.08 (0.77-1.53) | 1.76 (1.14-2.74) |
| Model 3 | 1 (reference) | 0.96 (0.77-1.19) | 1.12 (0.86-1.47) | 1.08 (0.76-1.53) | 1.75 (1.12-2.75) |
| All-cause hospitalization | |||||
| Model 1 | 1 (reference) | 1.02 (0.91-1.14) | 1.11 (0.99-1.25) | 1.29 (1.07-1.54) | 1.56 (1.11-2.18) |
| Model 2 | 1 (reference) | 1.03 (0.91-1.16) | 1.11 (0.99-1.25) | 1.29 (1.07-1.55) | 1.57 (1.14-2.15) |
| Model 3 | 1 (reference) | 1.03 (0.91-1.16) | 1.10 (0.98-1.23) | 1.29 (1.07-1.55) | 1.56 (1.13-2.13) |
| CV-related mortality or hospitalization | |||||
| Model 1 | 1 (reference) | 1.02 (0.84-1.22) | 0.98 (0.80-1.20) | 1.12 (0.83-1.52) | 1.84 (1.22-2.75) |
| Model 2 | 1 (reference) | 1.03 (0.85-1.25) | 0.98 (0.80-1.20) | 1.12 (0.83-1.53) | 1.81 (1.22-2.69) |
| Model 3 | 1 (reference) | 1.03 (0.85-1.25) | 0.96 (0.78-1.18) | 1.12 (0.82-1.53) | 1.82 (1.24-2.69) |
| Infection-related mortality or hospitalization | |||||
| Model 1 | 1 (reference) | 1.01 (0.83-1.22) | 1.16 (0.89-1.53) | 1.27 (0.95-1.69) | 1.36 (0.80-2.31) |
| Model 2 | 1 (reference) | 1.02 (0.84-1.24) | 1.17 (0.89-1.54) | 1.26 (0.94-1.68) | 1.36 (0.81-2.30) |
| Model 3 | 1 (reference) | 1.02 (0.84-1.25) | 1.15 (0.88-1.52) | 1.27 (0.94-1.70) | 1.37 (0.81-2.31) |
Note: Models stratified by country, phase, and accounting for facility clustering.
Abbreviations: CKD, chronic kidney disease; CI, confidence interval; CV, cardiovascular; eGFR, estimated glomerular filtration rate; HR, hazard ratio; KRT, kidney replacement therapy.
Model 1: adjusted for age, sex, African American race, 13 summary comorbid conditions, and eGFR.
Model 2: Model 1 + serum albumin level.
Model 3: Model 2 + albuminuria categories.