Table 3.
Association of serum uric acid with lung function in different models in male and female population.
| Variable | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|
| β (95% CI) | P-value | β (95% CI) | P-value | β (95% CI) | P-value | |
| For FEV1 (ml) in male (n = 3684 in each model) | ||||||
| UA (mg/dl) | − 0.91 (− 20.86, 19.04) | 0.9285 | − 16.63 (− 32.43, − 0.83) | 0.0392 | − 24.07 (− 41.37, − 6.77) | 0.0064 |
| UA (mg/dl) in tertile | ||||||
| Tertile 1 | Reference | Reference | Reference | |||
| Tertile 2 | 10.11 (− 74.44, 94.67) | 0.8147 | − 53.68 (− 120.54, 13.17) | 0.1156 | − 66.51 (− 132.55, − 0.46) | 0.0485 |
| Tertile 3 | 19.77 (− 59.06, 98.60) | 0.6231 | − 51.83 (− 114.34, 10.67) | 0.1042 | − 74.38 (− 138.38, − 10.39) | 0.0228 |
| For FVC (ml) in male (n = 3684 in each model) | ||||||
| UA (mg/dl) | 1.36 (− 22.42, 25.14) | 0.9107 | − 19.31 (− 39.58, 0.95) | 0.0618 | − 30.06 (− 52.26, − 7.85) | 0.0080 |
| UA (mg/dl) in tertile | ||||||
| Tertile 1 | Reference | Reference | Reference | |||
| Tertile 2 | 14.07 (− 86.72, 114.85) | 0.7844 | − 58.74 (− 144.50, 27.01) | 0.1795 | − 68.86 (− 153.66, 15.93) | 0.1115 |
| Tertile 3 | 41.38 (− 52.58, 135.34) | 0.3881 | − 54.72 (− 134.89, 25.46) | 0.1811 | − 82.29 (− 164.45, − 0.12) | 0.0497 |
| For FEV1 (ml) in female (n = 3830 in each model) | ||||||
| UA (mg/dl) | − 94.31 (− 110.91, − 77.72) | < 0.0001 | − 32.93 (− 45.31, − 20.55) | < 0.0001 | − 32.57 (− 46.96, − 18.17) | < 0.0001 |
| UA (mg/dl) in tertile | ||||||
| Tertile 1 | Reference | Reference | Reference | |||
| Tertile 2 | − 146.57 (− 187.55, − 105.59) | < 0.0001 | − 61.78 (− 91.95, − 31.61) | < 0.0001 | − 53.83 (− 85.05, − 22.62) | 0.0007 |
| Tertile 3 | − 281.94 (− 334.68, − 229.19) | < 0.0001 | − 95.76 (− 135.06, − 56.45) | < 0.0001 | − 83.52 (− 126.59, − 40.45) | 0.0001 |
| For FVC (ml) in female (n = 3830 in each model) | ||||||
| UA (mg/dl) | − 103.87 (− 122.91, − 84.82) | < 0.0001 | − 48.71 (− 64.51, − 32.91) | < 0.0001 | − 44.44 (− 62.65, − 26.23) | < 0.0001 |
| UA (mg/dl) in tertile | ||||||
| Tertile 1 | Reference | Reference | Reference | |||
| Tertile 2 | − 147.21 (− 194.29, − 100.13) | < 0.0001 | − 68.43 (− 106.97, − 29.89) | 0.0005 | − 51.26 (− 90.76, − 11.75) | 0.0110 |
| Tertile 3 | − 306.34 (− 366.94, − 245.74) | < 0.0001 | − 141.44 (− 191.65, − 91.24) | < 0.0001 | − 113.05 (− 167.55, − 58.55) | < 0.0001 |
Model 1, no covariates were adjusted.
Model 2, Age and race was adjusted.
Model 3, Age, race, income-poverty ratio, BMI, alcohol drinking, smoke, systolic blood pressure, diastolic blood pressure, blood urea nitrogen, total cholesterol, creatinine, calcium, total protein, FeNO and total bilirubin were adjusted.
FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; UA: uric acid.