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Diagram of the preparation and function of MSN+miR-146a for bone regeneration with an inflammatory microenvironment. a MSNs were synthesized from SiO2 nanoparticles and modified with PEI, and miR-146a was then loaded via physical absorption and electrostatic attraction. b The MSN+miR-146a complex significantly accelerated the osteogenesis of hDPSCs, reduced M1-type macrophages, increased M2-type macrophages, and promoted bone regeneration in infected mandibular bone defects in mice
