Fig. 3.
Ube2m-deficient mice were protected from lupus. a Representative photographs of spleens from WT, Ube2m-/-, WTlpr and Ube2m-/-lpr mice at 8 months. b, c Spleen index and the number of splenocytes were calculated. n = 4 or 5/group. ***P < 0.001. d, e The serum was collected at 8 months then level of IgG and anti-dsDNA antibodies were measured. n = 4 or 5/group. **P < 0.01. f, g Total protein, albumin and creatinine in urine were assessed and albumin/creatinine was calculated. n = 4 or 5/group. *P < 0.05, **P < 0.01, ***P < 0.001. h, i Representative images of PAS and HE staining from kidneys of 8-month-old mice were shown. Scale bar = 50 µm. Then, pathological score was calculated. n = 4 or 5/group. *P < 0.05, ***P < 0.001. j Cytokine profile in serum was measured using Bio-Plex ProTM Mouse Cytokine Th17 panel A6-plex. n = 4 or 5/group. *P < 0.05, **P < 0.01