Table 2.
Exosomal cargos exhibiting anti-tumor effect on OSCCs
| Exo-cargo | Origin | Function | Mechanism | Research model | Ref |
|---|---|---|---|---|---|
| miR-1294 | OSCC tissue | Inhibiting OSCC cells proliferation and migration | Targeting oncogene c-Myc | OSCC cell lines | 134 |
| miR-101-3p | Bone marrow mesenchymal stem cells (BMSCs) | Inhibiting OSCC occurrence and progression | Targeting collagen type X alpha 1 chain (COL10A1) |
OSCC cell lines Nude mice |
135 |
| miR-6887-5p | Eldecalcitol (ED71)-induced OSCC cells | Inhibiting OSCC cells proliferation | Targeting Heparin-binding protein 17/fibroblast growth factor–binding protein-1 (HBp17/FGFBP-1) |
OSCC cell lines Nude mice |
136 |
| miR-34a | Engineered exosomes from HEK-293T cells with miR-34a loading | Inhibiting OSCC cells proliferation, migration, and invasion | Targeting special AT-rich sequence-binding protein 2 (SATB2) | OSCC cells-HN6 | 137 |
| circRNA GDP dissociation inhibitor 2 (circGDI2) | Engineered exosomes from OSCC cells with circGDI2 loading | Inhibiting OSCC cells proliferation, migration, invasion and glycolysis | Regulating miR-424-5p and suppressor of cancer cell invasion (SCAI) |
OSCC cell lines BALB/c mice |
138 |
| LncRNA LBX1-AS1 | Immunoglobulin kappa J region (RBPJ) overexpressed macrophages | Inhibiting OSCC cells proliferation, and invasion | Regulating miR-182-5p/FOXO3 pathway |
OSCC cell lines Nude mice |
133 |