Fig. 18.

Role of LysM-positive myelomonocytic cells for noise-induced inflammation and damage. Genetic ablation by treatment of mice with LysM-positive cell (myelomonocytic) transgenic expression of an inducible diphtheria toxin receptor (LysM^iDTR) with low dose diphtheria toxin [465]. Mice free of LysM-positive cells showed no noise-dependent vascular infiltration of monocytes, macrophages, or granulocytes. They preserved endothelial function, normal blood pressure, and no aortic oxidative stress, indicating that LysM-positive cell ablation protects the vasculature from noise-induced damage. In contrast, microglia in the brain of LysM^iDTR mice were not ablated by diphtheria toxin, and noise-induced neuroinflammation, cerebral oxidative stress and release of stress hormones were not prevented. The image was created using Biorender.com. Modified from Ref. [187], based on data in Ref. [281] with permission. Copyright © 2021 the authors.