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. 2024 Jan 1;15(4):966–980. doi: 10.7150/jca.89135

Figure 8.

Figure 8

CANX overexpression re-activates cancer malignancy after inhibition of circFAM126A or overexpression of miR-505-3p. Sh-circFAM126A and miR-505-3p mimic were co-transfected into PC-3 and DU145 cells. A: The impact of co-transfection on miR-505-3p levels in cells was measured using RT-qPCR. B: Cell proliferation rate was assessed through the CCK-8 assay. C: Colony formation assay was conducted to evaluate the cell proliferation capacity. D: EdU incorporation was used to detect the rate of Edu-positive cells. E: Flow cytometry was performed to examine cell apoptosis. F and G: Transwell assays were utilized to assess the migration and invasion capabilities of the cells. H and I: Commercial kits were employed to measure the levels of TG and cholesterol in the cells. J and K: mRNA levels of LUR1 and SREBPs in the cells were detected by RT-qPCR. Data are presented as mean ± SD (n = 3), with * P < 0.05 indicating statistical significance.