Comparison 1. Folic acid‐based homocysteine lowering versus control.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Achieved change in homocysteine levels	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
2 Cardiovascular mortality	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
3 All‐cause mortality	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
4 Myocardial infarction (fatal and non‐fatal)	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
5 Coronary revascularization	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
6 Stroke (fatal and non‐fatal)	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
7 Cerebrovascular revascularization	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
8 Commencement of renal replacement therapy	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
9 Adverse events: gastrointestinal	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
10 All reported adverse events	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected