Study	Reason for exclusion
Ardalan 2003	Not RCT
Austen 2006	Cross‐over study
Beaulieu 1999	< 100 patient‐years. No clinical events, only plasma homocysteine levels
Biagini 2002	< 100 patient‐years. No clinical events, only carotid intima‐media thickness
Bostom 1997	< 100 patient‐years. No clinical events, only plasma homocysteine levels
Bostom 2000	Not a comparison of homocysteine lowering
Jurewicz 2003	Not a comparison of homocysteine lowering
Juskowa 2006	Not a comparison of homocysteine lowering
LANDMARK 2 Study 2009	Not a comparison of homocysteine lowering
Lash 1998	Not a comparison of homocysteine lowering
Manrique 2005	< 100 patient‐years
Marcucci 2002	< 100 patient‐years. No clinical events, only carotid intima‐media thickness
Nafar 2009	< 100 patient‐years. This study has been terminated according to ClinicalTrials.gov information
Perez 2004	< 100 patient‐years. No clinical events. Only clinical markers such as lipid profile
Rymarz 2009	Sequential or cross‐over design
Savaj 2002	Not RCT
Shemin 2001	Not RCT
Teplan 2003b	Not homocysteine lowering (hypoenergetic hypolipidaemic diet and corticosteroids withdrawal)
Xu 2005a	< 100 patient‐years. No clinical events. Only plasma homocysteine levels and endothelium dependent and independent vasodilation responses