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Corin loss and CHAF‐LA syndrome. A homozygous loss‐of‐function variant in the gene encoding the atrial natriuretic peptide (ANP)‐converting enzyme Corin leads to the absence of mature and active ANP and causes a disorder characterized by cardiomyopathy, hypertension, arrhythmia and fibrosis of the left atrium (CHAF‐LA syndrome).
