Table 3.
Univariate model for “MRI activity”.
| Independent Variable* | Univariable Analysis | |
|---|---|---|
| OR (95% CI) | P value | |
| Sex | 1.80 (0.50-5.14) | 0.789 |
| Age (years) | 1.05 (0.91-1.09) | 0.935 |
| Disease duration (years) | 0.61 (0.35-1.04) | 0.073 |
| N. of DMTs before OCR | 0.25 (0.04-1.42) | 0.121 |
| EDSS before infusion a | 0.64 (0.40-1.04) | 0.073 |
| Patients with relapses in the year before infusion a | 0.41 (0.08-3.12) | 0.663 |
| Patients with MRI activity in the year (1-3) before infusion a | 1.55 (0.98-6.47) | 0.291 |
| Time on OCR therapy (from start to infusion a, months) | 0.92 (0.84-1.01) | 0.087 |
| EID | 0.68 (0.11-4.00) | 0.676 |
| CD19+ B-cell depletion rate before infusion c | 1.05 (0.18-6.07) | 0.955 |
Abbreviations: OR, odds ratio; DMTs, disease modifying therapies; EID, extended interval dosing; EDSS, expanded disability status scale; MRI, magnetic resonance imaging; N. number; OCR, ocrelizumab.
Note: *For dichotomic variables, the last category was used as reference.