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(A) SOS1 X-ray cocrystal structure of MRTX0902 (PDB 7UKR) bound in site-A. (B) SOS1 X-ray crystal structure of MRTX0902 (PDB 7UKR) superimposed with the KRAS–SOS1 complex (PDB 6EPL). (C) Overlay of SOS1/BAY-293 X-ray cocrystal structure (magenta, PDB 5OVI) with apo SOS2 X-ray crystal structure (green, PDB 6EIE).
