Table 1. SPR K_D's for SPR and TINS Fragment Hits 7–14 Submitted for SOS2 X-Ray Crystallography.

^aK_D is based on n ≥ 2 with SEM within 0.2 units.

^bNS: nonsaturable binding.

^cSolubility measured by ¹H NMR in DPBS buffer at pH 7.2.

^dSolubility measured by total light and dynamic light scattering in 1× PBS buffer at pH 7.4.