Table 10. Antimycobacterial Activities of Compounds T6030, T6053, 67b, 67c, 69c, and 69e against M.tb. H37Ra Overproducing DprE1/2 Expressed as MIC.
| BTZ-043 (ng/mL) | T6030 (μM) | T6053 (μM) | 67b (μM) | 67c (μM) | 69c (μM) | 69e (μM) | |
|---|---|---|---|---|---|---|---|
| pVV2 | 1 | 0.3 | 0.18 | 0.125 | 0.5–1.5 | 3 | 0.25–0.5 |
| pVV2-dprE1/2 | >30 | 0.09–0.3 | 0.18 | 1.5 | 1.5 | 1–3 | 3 |