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. 2023 Dec 29;67(1):81–109. doi: 10.1021/acs.jmedchem.3c00925

Table 4. In Vitro Antimycobacterial Activities of the Compounds with (5-Nitropyridin-3-yl)methyl (82a–e) and (5-Nitrofuran-2-yl)methyl (83a–e) Groups Expressed as MIC (μM) and Their Comparison with Those of Parent Oxadiazoles 2a–e13.

graphic file with name jm3c00925_0017.jpg

  M. tuberculosis My 331/88a M. avium My 330/88a M. kansasii My 235/80b
INH 0.5/1 250/250 250/250/250
pretomanid 0.125/0.25 >32/>32 >32/>32/>32
2a 0.06/0.06 16/32 0.5/1/1
2b 0.125/0.125 16/32 0.125/0.25/0.25
2c 0.125/0.125 >125/>125 0.125/0.25/0.25
2d 0.125/0.125 250/250 0.125/0.25/0.5
2e ≤0.03/≤0.03 >32/>32 0.06/0.125/0.25
82a 125/250 250/250 125/250/250
82b 16/16 250/250 16/16/32
82c 4/8 >1000/>1000 8/8/16
82d 16/16 >1000/>1000 8/16/16
82e 16/16 1000/1000 8/16/16
83a 16/32 32/62 32/>32/>32
83b >32/>32 64/64 >32/>32/>32
83c 16/32 32/32 >32/>32/>32
83d 8/16 16/32 16/16/32
83e 0.5/1 32/32 4/8/16
a

14/21 days.

b

7/14/21 days.