Table 5. In Vitro Antimycobacterial Activities of the Tetrazole-Based Compounds 66a–e and 67a–e with 3,4-Dinitrobenzyl and 2,5-Dinitrobenzyl Groups, Respectively, and Trifluoromethyl Analogues of the Latter with 5-Trifluoromethyl and 2-Trifluoromethyl Groups 70a–e and 71a–e, Respectively, Expressed as MIC (μM) and Their Comparison with Those of Parent Tetrazoles 1a–e¹².

	X	M. tuberculosis My 331/88a	M. avium My 330/88a	M. kansasii My 235/80b
INH		0.5/1	250/250	250/250/250
pretomanid		0.125/0.25	>32/>32	>32/>32/>32
1a	3-NO2	4/4	62/62	2/4/16
1b	3-NO2	2/4	16/32	1/4/4
1c	3-NO2	1/2	125/125	2/4/4
1d	3-NO2	1/1	125/125	1/2/2
1e	3-NO2	1/1	16/32	4/4/4
66a	4-NO2	16/16	32/32	16/32/32
66b	4-NO2	32/32	125/125	16/32/32
66c	4-NO2	4/8	250/250	2/4/8
66d	4-NO2	16/16	250/250	8/16/16
66e	4-NO2	32/64	>1000/>1000	32/64/125
67a	2-NO2	1/1	250/250	2/4/4
67b	2-NO2	0.5/1	250/250	1/1/1
67c	2-NO2	0.5/1	250/250	1/1/2
67d	2-NO2	1/1	250/250	1/1/2
67e	2-NO2	1/1	250/250	1/1/1
70a	-	250/250	250/250	125/250/250
70b–70e	-	250/250	250/250	250/250/250
71a	2-CF3	32/32	250/250	64/132/250
71b	2-CF3	8/8	250/250	32/32/32
71c	2-CF3	250/250	250/250	250/250/250
71d	2-CF3	250/250	250/250	250/250/250
71e	2-CF3	32/32	250/250	64/64/64

^a14/21 days.

^b7/14/21 days.