Table 7. In Vitro Antimycobacterial Activities of the 3,5-Dinitrobenzysulfanyl Tetrazoles with Additional Methoxy Group (74a–e and 75a–e) or Methyl Group (76a–e and 77a–e) on 3,5-Dinitrophenyl Moiety Expressed as MICs (μM) and Their Comparison with Those of Parent Tetrazoles 1a–e¹².

	R1	R2	M. tuberculosis My 331/88a	M. avium My 330/88a	M. kansasii My 235/80b
INH			0.5/1	250/250	250/250/250
pretomanid			0.125/0.25	>32/>32	>32/>32/>32
1a	H	H	4/4	62/62	2/4/16
1b	H	H	2/4	16/32	1/4/4
1c	H	H	1/2	125/125	2/4/4
1d	H	H	1/1	125/125	1/2/2
1e	H	H	1/1	16/32	4/4/4
74a	OCH3	H	250/250	250/250	250/250/250
74b	OCH3	H	16/32	250/250	250/250/250
74c	OCH3	H	16/32	250/250	250/250/250
74d	OCH3	H	>32/>32	250/250	>32/>32/>32
74e	OCH3	H	32/32	>1000/>1000	16/32/32
75a	H	OCH3	>32/>32	250/250	>32/>32/>32
75b	H	OCH3	16/32	250/250	8/16/32
75c	H	OCH3	8/16	250/250	8/16/32
75d	H	OCH3	8/16	250/250	8/16/32
75e	H	OCH3	32/64	250/250	32/64/125
76a	CH3	H	4/8	250/250	2/4/8
76b	CH3	H	4/4	500/500	8/8/16
76c	CH3	H	2/2	250/250	1/2/4
76d	CH3	H	2/2	500/500	2/4/4
76e	CH3	H	4/8	250/250	8/16/32
77a	H	CH3	>32/>32	250/250	32/>32/>32
77b	H	CH3	16/16	250/250	8/16/32
77c	H	CH3	16/32	250/250	8/16/32
77d	H	CH3	32/32	64/64	32/32/32
77e	H	CH3	250/250	250/250	250/250/250

^a14/21 days.

^b7/14/21 days.