Table 8. In Vitro Antimycobacterial Activities of the 3,5-Dinitrobenzysulfanyl Oxadiazoles with Additional Methoxy Group (78a–e and 79a–e) or Methyl Group (80a–e and 81a–e) on 3,5-Dinitrophenyl Moiety Expressed as MICs (μM) and Their Comparison with Those of Parent Oxadiazoles 2a–e¹³.

	R1	R2	M. tuberculosis My 331/88a	M. avium My 330/88a	M. kansasii My 235/80b
INH			0.5/1	250/250	250/250/250
pretomanid			0.125/0.25	>32/>32	>32/>32/>32
2a	H	H	0.06/0.06	16/32	0.5/1/1
2b	H	H	0.125/0.125	16/32	0.125/0.25/0.25
2c	H	H	0.125/0.125	>125/>125	0.125/0.25/0.25
2d	H	H	0.125/0.125	250/250	0.125/0.25/0.5
2e	H	H	≤0.03/≤0.03	>32/>32	0.06/0.125/0.25
78a	OCH3	H	16/16	250/250	4/8/16
78b	OCH3	H	16/16	250/250	4/8/16
78c	OCH3	H	8/16	250/250	8/16/16
78d	OCH3	H	250/250	250/250	250/250/250
78e	OCH3	H	250/250	250/250	250/250/250
79a	H	OCH3	1/2	250/250	2/8/16
79b	H	OCH3	2/2	500/500	1/2/4
79c	H	OCH3	2/2	500/500	1/2/2
79d	H	OCH3	0.5/1	250/250	2/2/4
79e	H	OCH3	1/1	250/250	1/1/1
80a	CH3	H	>32/>32	250/250	32/>32/>32
80b	CH3	H	250/250	250/250	250/250/250
80c	CH3	H	32/>32	250/250	16/32/>32
80d	CH3	H	>32/>32	250/250	>32/>32/>32
80e	CH3	H	125/250	250/250	250/250/250
81a	H	CH3	2/2	250/250	1/2/4
81b	H	CH3	2/4	250/250	2/4/8
81c	H	CH3	2/2	250/250	2/4/8
81d	H	CH3	2/2	250/250	2/4/8
81e	H	CH3	2/2	250/250	8/16/32

^a14/21 days.

^b7/14/21 days.