Table 9. Antimycobacterial Activities of Compounds 56c, 61b, 67a-67c, 67e, 69a–69c, 69e, 79a, 79e, 81a, and 81e and Standard Anti-TB Drugs against Seven Clinically Isolated MDR/XDR-TB Strains Expressed as MIC (μM)a.
| MDR/XDR M.tb. strain |
|||||||
|---|---|---|---|---|---|---|---|
| Praha 1 | Praha 4 | Praha 131 | 9449/2007 | 234/2005 | 7357/1998 | 8666/2010 | |
| 56c | 4/8 | 4/8 | 4/8 | 4/8 | 4/8 | 4/8 | 4/8 |
| 61b | 8/8 | 8/8 | 8/8 | 8/8 | 8/8 | 8/8 | 8/8 |
| 67a | 1/2 | 0.5/1 | 0.5/1 | 1/1 | 1/1 | 1/1 | 1/1 |
| 67b | 0.5/1 | 0.25/0.5 | 0.25/0.5 | 0.25/0.5 | 0.5/1 | 0.5/1 | 0.5/1 |
| 67c | 0.5/1 | 0.25/0.5 | 0.25/0.5 | 0.5/1 | 0.5/1 | 0.5/1 | 0.5/0.5 |
| 67e | 1/2 | 1/1 | 1/1 | 1/1 | 0.5/1 | 0.5/1 | 0.5/0.5 |
| 69a | 1/2 | 0.5/1 | 0.5/1 | 0.5/1 | 0.5/1 | 0.5/1 | 0.5/0.5 |
| 69b | 1/1 | 0.5/1 | 0.5/1 | 1/1 | 0.5/1 | 0.5/1 | 0.5/0.5 |
| 69c | 1/1 | 0.5/1 | 0.5/1 | 1/2 | 0.5/1 | 0.5/1 | 0.5/0.5 |
| 69e | 1/1 | 0.5/1 | 0.5/1 | 0.5/1 | 0.5/1 | 0.5/1 | 0.25/0.5 |
| 79a | 2/4 | 1/2 | 1/2 | 2/2 | 1/2 | 1/2 | 1/2 |
| 79e | 1/2 | 0.5/1 | 0.5/1 | 1/1 | 1/1 | 1/1 | 1/1 |
| 81a | 2/4 | 2/4 | 2/4 | 2/4 | 2/4 | 2/4 | 2/4 |
| 81e | 2/4 | 1/2 | 2/2 | 4/4 | 2/2 | 1/2 | 1/2 |
| streptomycin | 16 (R) | >32 (R) | >32 (R) | >32 (R) | 32 (R) | >32 (R) | >32 (R) |
| isoniazid | 16 (R) | 16 (R) | 16 (R) | 64 (R) | 16 (R) | 16 (R) | 32 (R) |
| ethambutol | 32 (R) | 16 (R) | 32 (R) | 8 (S) | 16 (R) | 16 (R) | 16 (R) |
| rifampin | >8 (R) | >8 (R) | >8 (R) | >8 (R) | >8 (R) | >8 (R) | >8 (R) |
| ofloxacin | 1 (S) | >16 (R) | 16 (R) | 2 (S) | 0.5 (S) | 8 (R) | 8 (R) |
| gentamicin | 1 (S) | 0.5 (S) | >8 (R) | 1 (S) | 0.25 (S) | 1 (S) | 2 (S) |
| clofazimine | 0.5 (R) | 0.5 (R) | 0.25 (S) | 0.125 (S) | 0.125 (S) | 0.125 (S) | 2 (R) |
| amikacin | 0.5 (S) | 1 (S) | >32 (R) | 0.5 (S) | 0.5 (S) | 1 (S) | 2 (S) |
| pretomanid | n.d. | n.d. | 0.25 | 0.125 | n.d. | n.d. | 0.25 |
a
S, Strain susceptible to the given antibiotic drug. R, Strain resistant to the given antibiotic drug. n.d., not determined.