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Biochemical assay results obtained testing electrophilic MiniFrags (84 + 58 covalent heterocycles) against HDAC8 represented in IC50 values (micromolar, 1 h preincubation, 10 nM HDAC8). Blue dots indicate the position of the warhead. The coloring is in line with the activity, from red (low) through yellow (moderate) to green (high). N.A. stands for “not available”.
