Table 1. Human Liver Microsomal t_1/2 and BRDT Binding Data for JQ1 and Fluorinated Analogs (0.1 mg/mL Microsomal Protein).

	t1/2 (min)	Kd (nM)
(+)-JQ1	49	188
(+)-JQ1-F1	52	722
(+)-JQ1-F2	125	3920