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. 2024 Jan 2;15(1):107–115. doi: 10.1021/acsmedchemlett.3c00464

Table 2. Microsomal t1/2 (min) for (+)-JQ1 and (+)-JQ1-D (0.5 mg/mL Microsomal Protein).

  MLM HLM
(+)-JQ1 11.0 7.9
(+)-JQ1-D 19.8 22.5
fold improvement 1.8 2.8