Table 3. Pharmacokinetic Parameters for (+)-JQ1 and (+)-JQ1-D in Mice.
male (n = 4) |
female (n = 4) |
|||
---|---|---|---|---|
(+)-JQ1 | (+)-JQ1-D | (+)-JQ1 | (+)-JQ1-D | |
AUC0–t (μg mL–1 h–1) | 75.1 | 94.2 | 41.1 | 50.5 |
CL/Fobs (mg (μg/mL)−1 h–1) | 0.661 | 0.528 | 1.22 | 0.989 |
t1/2 (h) | 3.36 | 3.01 | 1.93 | 2.46 |