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. 2024 Jan 2;15(1):107–115. doi: 10.1021/acsmedchemlett.3c00464

Table 3. Pharmacokinetic Parameters for (+)-JQ1 and (+)-JQ1-D in Mice.

  male (n = 4)
female (n = 4)
  (+)-JQ1 (+)-JQ1-D (+)-JQ1 (+)-JQ1-D
AUC0–t (μg mL–1 h–1) 75.1 94.2 41.1 50.5
CL/Fobs (mg (μg/mL)−1 h–1) 0.661 0.528 1.22 0.989
t1/2 (h) 3.36 3.01 1.93 2.46