Table 2.

Tested compounds promoting or counteracting migraine mechanical hypersensitivity and/or allodynia

TRP channels	Migraine mechanical hypersensitivity and/or allodynia		References
	Activated by	Blocked by
TRPV1	Capsaicin Other vanilloids Acid Heat	Capsazepine JNJ-38893777 JNJ-17203212 XPro1595 SB-705498	[50, 54–56]
TRPV4	4α-PDD	RN1734 GSK-2193874	[57, 58]
TRPA1	Mustard oil Umbellulone Cinnamaldehyde	HC-030031	[58, 59]
TRPM3	Pregnenolone sulfate CIM0216	progesterone estrogenes	[59]
TRPM8	Cold Cooling substances (e.g. menthol)	AMG2850 RGM8-51 AMTB	[58, 60–62]
TRPC4	Lysophosphatidylcholine	ML204	[63]
TRPC5		CFA injections Paclitaxel	[56, 64]