Table 2. Current Synthetic Ligands Acting as α7 nAChR Antagonists^a.

^ah: human; K_d: dissociation constant; K_A: antagonist dissociation constant); IC₅₀: inhibitory concentration at 50%. Electrophysiology of nAChRs expressed in Xenopus oocytes.

^bFRET-based calcium sensor of nAChRs expressed in HEKtsA201 cells.

^cRadioligand analysis: inhibition of [³H]-(±)-epibatidine in nAChRs expressed in HEKtsA20, HEK293, or SH-EP1 cells

^dRadioligand analysis: inhibition of [¹²⁵I]-α-bungarotoxin and [³H]-(±)-epibatidine in chick brain

^eRadioligand analysis: inhibition of [¹²⁵I]-α-bungarotoxin in SH-SY5Y human neuroblastoma cells