Table 3. Comparison of Physiochemical and Drug-like Parameters for Selected Compounds 2, 14, and 28.
a
Half-maximal effective concentration in inhibiting N. fowleri trophozoite viability.
b
Half-maximal cytotoxic concentration after 72 h in human neuronal SH-SY5Y cells.
c
Kinetic solubility, PBS buffer.
d
Sourced from CD-1 mouse.
e
2 μM protein concentration
f
10 μM compound concentration; porcine brain lipid extract; 4 h incubation; negative control (CNS−): nadalol, Pe < 0.1 nm/s; positive control (CNS+): carbamazepine, Pe = 66.3 nm/s. ND = not determined.