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. Author manuscript; available in PMC: 2024 Jan 15.
Published in final edited form as: J Am Chem Soc. 2023 May 9;145(20):10901–10916. doi: 10.1021/jacs.3c00713

Figure 3. Supramolecular designs of collagen hybridizing peptides.

Figure 3.

(a) Designs of monomeric CHPs that do not self-trimerize but can inherently or be triggered to hybridize with denatured collagen. Adapted with permission from ref 50. Copyright 2018 Elsevier Ltd. (b) Concepts of the dimeric CHP designs to promote the hybridizing affinity and to limit the peptide self-association. Adapted with permission from ref 61 (Copyright 2019 Royal Society of Chemistry) and 115 (Copyright 2018 Wiley-VCH). (c) A cyclic dimeric CMP was designed to mimic the damaged collagen molecules for assessing triple-helix hybridization. Adapted with permission from ref 116. Copyright 2020 American Chemical Society. (d) CHP strands displayed on anti-parallel β-sheet nanofibers at distance were sterically restricted from self-trimerizing, but they provided the nanofibers the capacity to target denatured collagen in vivo. Adapted with permission from ref 66. Copyright 2017 American Chemical Society. (e) Design of the self-assembled elastin- and collagen-like peptide conjugate (ELP-CLP) nanovesicle. Adapted with permission from ref 67. Copyright 2017 American Chemical Society.