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. Author manuscript; available in PMC: 2024 Jan 15.
Published in final edited form as: Mol Cancer Ther. 2021 Feb 25;20(5):833–845. doi: 10.1158/1535-7163.MCT-20-0495

Figure 5.

Figure 5.

JNK activation is significant in ER-stress related apoptosis and death receptor regulation. A. Cell viability of DU145 and PC3 cells after pre- and post-treatement with 20 μM SP600125 (JNK inhibitor). B. TRAIL sensitization of DU145 and PC3 cells cells treated with JNK inhibitor before or after taxane (0.25 μM) therapy followed by TRAIL treatment. C. Western blot of death receptor expression in DU145 and PC3 cells treated with either CBZ, DTX, and JNK inhibitor alone or in combination. Cells were also treated with the JNK inhibitor before or after taxane exposure. D. Relative death receptor expression in DU145 and PC3 cells treated with either CBZ, DTX, and JNK inhibitor alone or in combination. Cells were also treated with the JNK inhibitor before or after taxane exposure. The values represent the mean ± SD (n=6 or 9). * p < 0.05, **** p< 0.0001.