Table 3.
Publications on neuropathic pain from the DOLORisk study.
| Study | Pain phenotype | Design | Main finding |
|---|---|---|---|
| Baskozos et al.6 | Diabetic peripheral neuropathy | CS | Machine learning techniques demonstrated that HRQoL, personality traits, HbA1c, depression, anxiety, age, and BMI were the most powerful predictors of the presence of in pain people with diabetic peripheral neuropathy |
| Bennedsgaard et al.11 | Chemotherapy-induced peripheral neuropathy in patients with breast cancer referred for surgery | Longitudinal | Polyneuropathy and pain symptoms more common in patients treated with chemotherapy than those without. In people treated with chemotherapy, pain in the feet was less common than pain at the surgical site but was more intense |
| Granovsky et al.52 | Diabetic polyneuropathy | CS | Heat pain CPM was more efficient in people with painful vs painless diabetic polyneuropathy. Efficient heat pain CPM associated with greater pain intensity in previous 24 h and greater loss of mechanical sensation. |
| Hébert et al.59 | General NP | Longitudinal | Multivariable risk models demonstrate that psychosocial and lifestyle factors predict the onset and resolution of neuropathic pain. The models demonstrated adequate discrimination and clinical utility over a range of risk thresholds |
| Themistocleous et al.119 | Diabetic/chemotherapy-induced distal symmetrical polyneuropathy | CS | There were no significant differences in sensory and motor axonal excitability measures between patients with painful and painless diabetic/chemotherapy-induced peripheral neuropathy |
| Topaz et al.120 | Diabetic polyneuropathy | CS | Advanced predictive analysis demonstrated that resting-state electroencephalography–based functional brain activity (cortical functional connectivity) can discriminate between painful and painless diabetic polyneuropathy |
| Veluchamy et al.124 | General NP | GWAS meta-analysis | 1 GWS significant locus (SLC25A3) and one suggestive locus (CAB39L) associated with NP. Gene expression in NP-associated brain and DRG tissue. Previously reported genetic variants failed to replicate |
BMI, body mass index; CAB39L, calcium binding protein 39 like; CPM, conditioned pain modulation; CS, cross-sectional; DRG, dorsal root ganglion; GWAS, Genome-Wide Association Study; GWS, genome-wide significant; HbA1c, glycated haemoglobin; HRQoL, health-related quality of life; SLC25A3, NP, neuropathic pain; solute carrier family 25 member 3.