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. 2024 Jan 15;6(1):e00181. doi: 10.1097/BS9.0000000000000181

Figure 1.

Figure 1.

The percentage of VISTA/PD-1/Tim-3/TIGIT+ T cells in PB and BM from patients with AL amyloidosis and HIs. (A) The analytic logic of flow cytometry detection of VISTA/PD-1/Tim-3/TIGIT expression within CD3+, CD4+, and CD8+ T cell subsets in PB or BM. (B) tSNE clusters of the global distribution and frequency of different phenotypes of T cells in the PB of patients with AL amyloidosis and HIs. (C) Comparison of the percentage of VISTA/PD-1/Tim-3/TIGIT+ T cells in PB between patients with AL amyloidosis (n = 19) and HIs (n = 19). (D) Comparison of the percentage of VISTA/PD-1/Tim-3/TIGIT+ T cells in BM between patients with AL amyloidosis (n = 19) and HIs (n = 10). (E) Comparison of the percentage of VISTA/PD-1/Tim-3/TIGIT+ T cells between PB and BM from 19 patients (P1–P16) with AL amyloidosis. AL = amyloid light chain, BM = bone marrow, HIs = healthy individuals, PB = peripheral blood, PD-1 = programmed cell death-1, TIGIT = T cell immunoreceptor with Ig and ITIM domains, Tim-3 = T cell immunoglobulin and mucin-domain-containing-3, tSNE = t-distributed stochastic neighbor embedding, VISTA = V-domain immunoglobulin suppressor of T cell activation.