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. Author manuscript; available in PMC: 2024 Jan 15.
Published in final edited form as: Cell Rep. 2023 May 11;42(5):112508. doi: 10.1016/j.celrep.2023.112508

Figure 3. Patients with high HPV E5 expression had lower immunoproteasome expression, which is associated with worse clinical outcomes.

Figure 3.

(A–C) Johns Hopkins University (JHU) cohort of HNSCC patients.

(A) Left: mRNA expression of immunoproteasome subunits analyzed by RNA-seq. (normal, n = 25; E2/E4/E5 high, n = 26; E6/E7 high, n = 10; median with interquartile range). Right: patients were assigned to one of three groups based on the mRNA expression level of immunoproteasome subunits (high, average, low). Patients with low and high expression are shown.

(B) Correlation analysis of HPV E5 expression and immunoproteasome subunits (n = 36, Spearman correlation coefficient).

(C) Disease-free survival and overall survival. Patients were assigned to groups based on HPV E5 and PSMB (immunoproteasome or constitutive proteasome subunits) expression level.