Skip to main content
. Author manuscript; available in PMC: 2024 Jan 15.
Published in final edited form as: Cell Rep. 2023 May 11;42(5):112508. doi: 10.1016/j.celrep.2023.112508

Figure 7. HPV E5 expression was inversely correlated with an IFN-inducible gene signature in the HNSCC patient cohort.

Figure 7.

(A–E) JHU cohort of HNSCC patients.

(A) Heatmap of IFN-inducible gene expression analyzed by RNA-seq (normal, n = 25; E2/E4/E5 high, n = 26; E6/E7 high, n = 10).

(B) Expression of the IFN-inducible gene signature in each group. Median with interquartile range.

(C) Correlation analysis of HPV E5, E6, or E7 expression and IFN-inducible gene signature (n = 36, Spearman correlation coefficient).

(D) Correlation analysis of HPV E5 and selected genes from the IFN-inducible gene signature.

(E) Overall survival and disease-free survival of patients with high IFN-inducible gene expression (indicated by red arrows in Figure 7A) and low expression (indicated by blue arrows) from the E2/E4/E5 high group (n = 9 per group).