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How does ISG65 reduce the effects of complement in African trypanosomes?
ISG65 (blue) is attached to the trypanosome plasma membrane (green) via a flexible string. This allows it to reach above the VSG surface (grey), where it can bind to C3 derivatives, including C3, C3b, and C3d. How it reduces the destruction of trypanosomes by the complement system is unknown. Abbreviations: ISG65, invariant surface glycoprotein 65; VSG, variant surface glycoprotein.
