Table 2.
Background characteristics and comparison of anthropometric and nutritional status at 12 months after LSG and after 12 months of semaglutide treatment.
| Before LSG | 12 months after LSG | p-value | Before semaglutide | After 12 months semaglutide | p-value | p-value LSG vs semaglutide | |
|---|---|---|---|---|---|---|---|
| VFA (cm2) | 210.3 (166.2–292.0) | 124.6 (93.3–194.1) | <0.001 | 210.9 (108.2–262.8) | 133.6 (86.4–209.8) | 0.011 | 0.034 |
| SFA (cm2) | 495.9 (425.3–666.7) | 373.8 (328.4–485.9) | 0.001 | 386.8 (319.2–636.4) | 359.0 (246.6–523.5) | 0.010 | 0.128 |
| Skeletal muscle ratio (%) | 28.0 (26.3–29.9) | 31.2 (29.1–36.6) | <0.001 | 30.5 (26.8–34.9) | 30.7 (28.0–34.9) | 0.538 | <0.001 |
| Hb (g/dl) | 14.2 ± 1.9 | 14.3 ± 1.8 | 0.747 | 14.5 ± 1.9 | 14.5 ± 1.7 | 1.000 | 0.763 |
| Alb (g/dl) | 4.2 ± 0.4 | 4.3 ± 0.4 | 0.164 | 4.1 ± 0.4 | 4.0 ± 0.4 | 0.082 | 0.048 |
| ChE (IU/L) | 379.0 ± 82.6 | 344.4 ± 73.7 | 0.025 | 355.6 ± 81.1 | 334.7 ± 80.1 | 0.041 | 0.973 |
| Vitamin B1 (μg/dl) | 4.8 (4.3–5.7) | 5.0 (4.3–5.4) | 0.877 | 4.6 (3.9–5.1) | 4.3 (3.7–5.0) | 0.222 | 0.586 |
| Vitamin B12 (pg/dl) | 447.0 (364.8–559.0) | 454.0 (368.0–568.5) | 0.520 | 522.0 (388.5–631.0) | 399.0 (343.0–589.3) | 0.007 | 0.039 |
| Folic Acid (ng/ml) | 9.7 (5.9–13.4) | 8.1 (5.7–13.5) | 0.488 | 8.1 (5.8–11.9) | 7.6 (5.4–14.8) | 0.550 | 0.375 |
| Vitamin D (ng/ml) | 13.6 (11.1–16.5) | 25.2 (12.2–30.8) | 0.039 | 23.2 (17.6–36.4) | 27.7 (17.6–39.3) | 0.279 | 0.076 |
| Zinc (μg/dl) | 71.5 (64.3–77.5) | 72.0 (62.3–80.0) | 0.849 | 78.0 (64.3–85.0) | 69.5 (59.5–79.0) | 0.023 | 0.100 |
| Iron (mg/dl) | 82.5 (68.5–109.5) | 98.0 (70.3–117.0) | 0.346 | 81.5 (61.0–94.3) | 81.5 (66.3–100.5) | 0.273 | 0.940 |
Data are presented as mean ± SD or median (interquartile range). VFA, Visceral fat area; SFA, subcutaneous fat area; Hb, hemoglobin; Alb, albumin; ChE, cholinesterase; LSG, laparoscopic sleeve gastrectomy.