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. 2023 Dec 12;300(1):105536. doi: 10.1016/j.jbc.2023.105536

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

HSP90 ATPase activity is required for PDCoV infection.A, schematic of infection and inhibitor treatment time course. Blue double-headed arrows indicate the presence of HSP90 inhibitors, and red double-headed arrows indicate the incubation with PDCoV. PDCoV M mRNA levels in PDCoV-infected LLC-PK cells treated with (B) 17-AAG, (E) VER-82576, and (H) KW-2478. Viral titer in the supernatants from PDCoV-infected cells treated with (C) 17-AAG, (F) VER-82576, and (I) KW-2478. Western blots of PDCoV N protein from PDCoV-infected cells treated with (D) 17-AAG, (G) VER-82576, and (J) KW-2478. HSP90, heat shock protein 90; PDCoV, porcine deltacoronavirus.