Table 1.
GO/KEGG analysis of DEGs from the GSE135697 dataset
| Term of GO/KEGG analysis | Count | P-value | Genes |
|---|---|---|---|
| WP3888: VEGFA-VEGFR2 signaling pathway | 10 | 1.7378E-05 | ABL1,ACACA,HBD,LDHA,TBCA,TKT,ADAM9,ATF6,EPN1,ACKR3 |
| GO:0006509⁓membrane protein ectodomain proteolysis | 3 | 9.12011E-05 | ADAM9,RBMX,APH1A,HDAC2,NEURL1B |
| R-HSA-389977: post-chaperonin tubulin folding pathway | 3 | 0.000104713 | TBCA,TUBA4A,TUBA1B,ABL1,HBD,HDAC2,PSMA5,RTN3,ATF6,APH1A,RAB18,SRGAP3,UPF3A,SNAP23,VRK2,ALG3,SCFD1,ST8SIA5,CLDN14 |
| GO:0043484⁓regulation of RNA splicing | 6 | 0.000109648 | CLK1,FUS,SRSF1,CELF2,RBMX,NSRP1,ECD,LSM1,NT5C3B,UPF3A |
| GO:0001975⁓response to amphetamine | 3 | 0.000269153 | DBH,EDNRA,HDAC2,ABL1,ACKR2,P2RY1,ACKR3,GPR37L1 |
| GO:0051603⁓proteolysis involved in cellular protein catabolic process | 10 | 0.000331131 | PSMA5,TRIM25,CUL4A,HERC2,ATF6,RCHY1,UCHL5,HECW2,RNF217,TRIM72,SAE1,NEURL1B,KLHL36,ABL1,KDM4A,TUBA4A,SNAP23,TUBA1B,COLEC12 |
| R-HSA-6794362: protein-protein interactions at synapses | 4 | 0.000489779 | PPFIA2,DLGAP1,NRXN2,RTN3,TUBA4A,TUBA1B |
| R-HSA-194315: signaling by Rho GTPases | 10 | 0.000831764 | ABL1,TUBA4A,VRK2,SNAP23,SRGAP3,TUBA1B,KDM4C,SCFD1,RBMX,ARHGAP15 |
| GO:0046777⁓protein autophosphorylation | 5 | 0.001202264 | ABL1,CLK1,GRK5,VRK2,TRPM7,PPFIA2,ADAM9 |
| GO:0003012⁓muscle system process | 6 | 0.001258925 | EDNRA,HDAC2,P2RY1,P2RX6,KDM4A,TRIM72,ABL1,HBD,SRGN,TUBA4A,TUBA1B,PDE10A,AKAP6 |
| GO:0007268⁓chemical synaptic transmission | 7 | 0.001513561 | DBH,SNAP23,P2RX6,DLGAP1,NRXN2,SV2C,RIMBP2 |
| GO:0009896⁓positive regulation of catabolic process | 8 | 0.001513561 | NRDC,ADAM9,ATF6,RCHY1,LSM1,HECW2,NT5C3B,RNF217,HDAC2,APH1A,UCHL5 |
| GO:2001020⁓regulation of response to DNA damage stimulus | 6 | 0.001949845 | ABL1,FUS,CUL4A,UCHL5,ACKR3,MEAF6 |
| GO:0044272⁓sulfur compound biosynthetic process | 4 | 0.002951209 | ACACA,MTRR,CSGALNACT1,DSEL,EDNRA |
| GO:0051259⁓protein complex oligomerization | 5 | 0.003801894 | ACACA,FUS,RBMX,TRPM7,TRIM72 |
| GO:2000736⁓regulation of stem cell differentiation | 3 | 0.003801894 | ABL1,HDAC2,KDM4C,GPR37L1,KDM4A,VRK2,MCM3AP,MEAF6,UCHL5 |
| R-HSA-5693565: recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double-strand breaks | 3 | 0.004265795 | ABL1,HERC2,KDM4A |
| GO:1901361⁓organic cyclic compound catabolic process | 6 | 0.005011872 | DBH,SNX17,PDE10A,LSM1,UPF3A,NT5C3B,PURA,RTN3,UNK,FUS,PSMA5,SRSF1,RPP14,RBMX |
| GO:0006897⁓endocytosis | 7 | 0.005248075 | ABL1,ACKR2,SNX17,EPN1,NEURL1B,ACKR3,COLEC12 |
| GO:0001701⁓in utero embryonic development | 6 | 0.005623413 | EDNRA,CUL4A,KDM4C,EPN1,NSRP1,UNK |
GO Gene Ontology, KEGG Kyoto Encyclopedia of Genes and Genomes, DEGs differentially expressed genes