Table 2.
GO/KEGG analysis of 84 overlapping genes between the predicted target genes of DEmiRs and the DEGs from the GSE135697 dataset
| Term of GO/KEGG analysis | Count | P-value | Genes |
|---|---|---|---|
| R-HSA-1257604:PIP3 activates AKT signaling | 9 | 6.0256E-08 | AKT2,XIAP,FGFR1,PDGFRB,PDPK1,PSMD7,PTEN,TNRC6A,TNRC6C,CACNA1C,RTN3,ATF6,BACE1,CLSPN,ENTPD1,IFNAR2,GCLC,KPNA3,RUNX1,DYRK1A |
| R-HSA-8943723: regulation of PTEN mRNA translation | 3 | 1.7378E-06 | PTEN,TNRC6A,TNRC6C,RUNX1,AKT2,FKBP4,PDPK1,SSRP1,CRADD,DYRK1A,TRAF3IP2,SERBP1,PSMD7 |
| GO:0030335⁓positive regulation of cell migration | 10 | 3.54813E-06 | AKT2,FGFR1,ITGA6,SERPINE1,PDGFRB,PDPK1,PTP4A1,ADAM9,FOXP1,EMC10,PTEN,ABL2,XIAP,RUNX1,IFNAR2,IL6ST,DYRK1A,TRPM7,PSMD7,BCL11A,STX17,CLSPN,LRP8,CRADD,GCLC,CACNA1C |
| GO:0031331⁓positive regulation of cellular catabolic process | 9 | 4.57088E-06 | AKT2,GCLC,PTEN,ADAM9,ATF6,ARIH1,TNRC6A,TNRC6C,SCOC,XIAP,BACE1,RUNX1,SERPINE1,CRADD,LRIG2,AZIN1,UBE2V1 |
| GO:0080135⁓regulation of cellular response to stress | 11 | 5.24807E-06 | XIAP,DYRK1A,PTEN,UBE2V1,LRIG2,ATF6,MAPKBP1,FAM168A,USP22,DDAH1,EMC10,FGFR1,PDGFRB,ADAM9 |
| R-HSA-202424: downstream TCR signaling | 5 | 8.12831E-06 | PDPK1,PSMD7,PTEN,UBE2V1,PEDS1-UBE2V1,UBE2D3,ABL2,AKT2,IFNAR2,IL6ST,KPNA3,ARIH1,CAPZB,UBE2D4,FKBP4 |
| R-HSA-2262752: cellular responses to stress | 11 | 1.12202E-05 | AKT2,CAPZB,FKBP4,GCLC,PSMD7,UBE2D3,PDIA5,HSPA4L,ATF6,TNRC6A,TNRC6C |
| GO:0032446⁓protein modification by small protein conjugation | 10 | 4.16869E-05 | XIAP,UBE2D3,UBE2V1,PCGF3,TRAF3IP2,USP22,ARIH1,UBE2D4,BCL11A,DCAF17,HSPA4L,ATF6,PSMD7,WDR26,AKT2 |
| GO:2001236⁓regulation of extrinsic apoptotic signaling pathway | 5 | 6.91831E-05 | FGFR1,GCLC,ITGA6,SERPINE1,PTEN,MNT,CRADD |
| hsa04218: cellular senescence | 5 | 7.58578E-05 | AKT2,SERPINE1,PTEN,TRAF3IP2,TRPM7,LRIG2,HOXA3,PDGFRB,EMC10,MAPKBP1,BACE1,FAM126B |
| GO:0045766⁓positive regulation of angiogenesis | 5 | 0.000165959 | RUNX1,SERPINE1,PDPK1,DDAH1,EMC10,XIAP |
| GO:0031345⁓negative regulation of cell projection organization | 5 | 0.000190546 | CAPZB,FKBP4,PTEN,LRIG2,BCL11A,ABL2,ITGA6,LRP8,DYRK1A,GCLC,TET1 |
| R-HSA-5683057: MAPK family signaling cascades | 6 | 0.000295121 | FGFR1,IL6ST,PDGFRB,PSMD7,TNRC6A,TNRC6C,AKT2,PCGF3,IFNAR2 |
| GO:0001655⁓urogenital system development | 6 | 0.000346737 | FKBP4,PDGFRB,PTEN,TFAP2A,TRAF3IP2,GLIS2,XIAP,CRADD,ITGA6,ATF6,BACE1 |
| GO:0060998⁓regulation of dendritic spine development | 3 | 0.000489779 | PTEN,LRP8,SDK1 |
| GO:0001654⁓eye development | 6 | 0.00057544 | CACNA1C,PBX2,PDGFRB,TFAP2A,ATF6,SDK1,ITGA6 |
| GO:0021675⁓nerve development | 3 | 0.001513561 | HOXA3,TFAP2A,LRIG2 |
| GO:1903829⁓positive regulation of protein localization | 6 | 0.001584893 | AKT2,PDPK1,UBE2D3,ADAM9,LRIG2,GLIS2,XIAP,FGFR1,TET1 |
| GO:0005975⁓carbohydrate metabolic process | 6 | 0.001698244 | AKT2,GCLC,IL6ST,PTEN,UGDH,MLEC,TFAP2A,BACE1 |
| GO:0097191⁓extrinsic apoptotic signaling pathway | 3 | 0.002041738 | PDPK1,CRADD,BLOC1S2 |
GO Gene Ontology, KEGG Kyoto Encyclopedia of Genes and Genomes, DEGs differentially expressed genes, DEmiRs differentially expressed miRNAs