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. 2024 Jan 15;14:1306. doi: 10.1038/s41598-023-50495-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Sankey diagram of the top features calculated across all the samples in the pan-tissue dataset. The visualization of XAI-AGE layer structure shows the normalized relative importance score difference between the old (>65 years) and young samples for various nodes inside each layer. Darker colours indicate a larger difference between the importance scores for the two age groups at the given node. Only the top 5 nodes in each layer are displayed here, where the other nodes are indicated by the single semi-transparent nodes (named residual) at the bottom for each layer.