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. 2024 Jan 16;8:11. doi: 10.1038/s41698-024-00503-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a, b Gene ontology analyses of differentially expressed genes after circCCDC7(15,16,17,18,19) overexpression in PC3 (a) and DU145 (b) cell lines. c Three downstream genes selected from the RNA-seq were examined with TCGA database and TCGA relapse-free survival analyses. d Relapse-free survival analysis of FLRT3 in TCGA. e Expression of FLRT3 in 134 pairs of PCa and normal margin samples from CPGEA. f, g Expression of FLRT3 in PCa and normal margin samples from TCGA (f) and GSE134051 (g). h, i Expression of FLRT3 in normal, localized and metastasis samples from GSE6919 (h) and GSE3325 (i). j Expression of FLRT3 protein in PCa samples of different grades from Proteinatlas. *p < 0.05, **p < 0.01, ****p < 0.0001.