Table 1.
Characteristics of the study cohort
| Characteristic | All participants N=6256 |
|---|---|
| Age, median [IQR] | 12.21 [7.87–21.28] |
| Male sex, n (%) | 3038 (48.6) |
| Number of AAbs, n (%) | |
| 0 | 180 (2.9) |
| 1 | 2470 (39.5) |
| 2 | 1451 (23.2) |
| 3 | 963 (15.4) |
| 4 | 741 (11.8) |
| 5 | 451 (7.2) |
| Type of AAb, n (%) | |
| GAD65+ | 4955 (79.2) |
| IA-2+ | 1900 (30.4) |
| mIAA+ | 2524 (40.3) |
| ICA+ | 2217 (35.4) |
| ZNT8+ | 1635 (26.1) |
| AAb ≥2, n (%) | 3606 (57.6) |
| HLA–DR3 and/or DR4a, n (%) | 4543 (79.1) |
| Dysglycaemia, n (%) | 1462 (23.4) |
| BMI, median [IQR] | 19.47 [16.28–24.49] |
| Adults aged ≥18, median [IQR], n | 26.09 [23.02–30.77], 1590 |
| Children <18, median [IQR], n | 17.39 [15.69–20.61], 4024 |
| BMIp, median [IQR] | 52.18 [42.24–61.07] |
| Adults aged ≥18, median [IQR], n | 42.61 [23.32–65.50], 1589 |
| Children <18, median [IQR], n | 53.26 [46.03–60.47], 4022 |
| Age of children <18 with a BMIp, median [IQR], n | 9.62 [6.58–12.82], 4022 |
| HOMA-IR, median [IQR] | 1.36 [0.84–2.18] |
| Matsuda Index, median [IQR] | 6.56 [4.23–10.26] |
| Index60, median [IQR] | 0.04 [−0.69, 0.71] |
| IGI, median [IQR] | 0.75 [0.41–1.31] |
aHLA typing information was unavailable for 514 individuals