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. 2024 Jan 15;15:258. doi: 10.1038/s41467-023-44520-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a App expression in adipose tissue (Mann Whitney test, U = 6; n = 12/group), the liver (n = 10 and 9/group respectively) and skeletal muscle (Sk. musc., quadriceps; unpaired t-tests; n = 12/group) from control and obese mice. b Bace1 expression in adipose tissue (Mann Whitney test, U = 1; n = 12/group), the liver (n = 9 and 8/group, respectively) and sk. musc. (unpaired t-tests; n = 12/group) from control and obese mice. c, Psen1 expression in adipose tissue (Mann Whitney test, U = 14; n = 10 and 12/group respectively), the liver (n = 12/group) and sk. musc. (n = 12/group) from control and obese mice (unpaired t-tests). d BACE1 activity in adipose tissue (n = 12 and 10/group respectively), the liver (n = 8/group) and sk. musc. (n = 8/group) from control and obese mice (unpaired t-tests). e relative release of Aβ isoforms from adipose tissue of control and obese mice normalised for tissue weight. f absolute release of Aβ isoforms from adipose tissue of control (n = 12) and obese (n = 11) mice (Mann Whitney test, U = 6). g plasma Aβ isoforms in control (n = 12) and obese (n = 11) mice (unpaired t-test). All data are mean ± SEM. Statistical tests are two-tailed. Source data are provided in the Source Data file.