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. 2023 Oct 10;45(2):339–353. doi: 10.1038/s41401-023-01175-7

Fig. 2. Lpar2−/− mice are more susceptible to IND-induced enteropathy than wild-type mice.

Fig. 2

IND (20 mg/kg) or its VEH were administered by gavage to wild-type (WT) and Lpar2−/− mice, and enteropathy-induced shortening of the small intestine (a) and histological injury (b, c) were assessed after 6 and 24 h. a, b: Circles represent the data of each mouse, bars indicate the mean + SEM. c Representative histological images (haematoxylin and eosin staining, low magnification scale bar: 1000 μm, high magnification scale bar: 200 μm) of the small intestines of IND-treated WT and Lpar2−/− mice, arrows mark mucosal lesions, characterized by epithelial loss and inflammatory infiltration. For statistical analysis two-way ANOVA (a) and Kruskal–Wallis test (b) were used, followed by Fisher’s LSD and uncorrected Dunn’s tests, respectively. n = 6–8/group, *P < 0.05, ***P < 0.001 compared to the respective VEH-treated group.