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. 2023 Oct 10;45(2):339–353. doi: 10.1038/s41401-023-01175-7

Fig. 5. The selective LPAR2 agonist DBIBB increases the shortening of small intestine but reduces the severity of mucosal damage in IND-treated mice.

Fig. 5

DBIBB (1 and 10 mg/kg) or its VEH were administered by gavage twice, 24 h and 30 min before the administration of IND (20 mg/kg). The length of small intestines (a) and histological injury (b, c) were assessed 24 h after IND treatment. a, b Circles represent the data of each mouse, bars indicate the mean + SEM. c Representative histological images (haematoxylin and eosin staining, low magnification scale bar: 1500 μm, high magnification scale bar: 250 μm) of the small intestines, white and black arrows denote ulcer and superficial epithelial damage, respectively, whereas asterisks denote mucosal edema. For statistical analysis one-way ANOVA (a) and Kruskal–Wallis test (b) were used, followed by Fisher’s LSD and uncorrected Dunn’s tests, respectively. n = 7/group, **P < 0.01, ***P < 0.001 compared to control (only VEH-treated) group, #P < 0.05 compared to “IND 20” group.