Fig. 8. The lack of LPAR2 increases, whereas activation of LPAR2 by DBIBB reduces caspase-3 activation.

a Tissue expression of total (C3) and cleaved caspase-3 (cC3) in wild-type (WT) and Lpar2^−/− mice treated with IND or VEH. b Correlation between caspase-3 activation and the severity of histological damage (R² = 0.25, P = 0.02). c Caspase-3 activation in WT mice treated with DBIBB. d–f The effects of DBIBB treatment on small intestinal length, histological scores and caspase-3 activation in NOD/SCID mice. Circles represent the data of each mouse, bars indicate the mean + SEM. For statistical analysis two-way ANOVA (a), Spearman test (b), one-way ANOVA (c, d, f) and Kruskal–Wallis test (e) were used. n = 6–7/group, *P < 0.05 compared to respective control (only VEH-treated) group, ^#P < 0.05 compared to “IND 30” group.