Table 1.

Model performance by cohort

	Stool microbiome				Human blood transcriptome
	Microbiome discovery cohort (cross-validated)	Microbiome Validation cohort (prospective)	Galkin et al. CV Host matched cohort	Galkin et al. Independent HC matched cohort	Blood transcriptome discovery cohort (cross-validated)
Cohort size	78,637	11,666	1164	252	1494
Sex (% female)	64.10	65.37	64.95	48.41	61.29
Age (y) mean $\pm$ s.d.	46.79 $\pm$ 15.9	43.22 $\pm$ 15.75	49.00 $\pm$ 15.35	48.06 $\pm$ 11.36	47.24 $\pm$ 14.22
Baseline MAE	12.98	12.90	13.03	9.36	11.75
Prediction R2	0.42 $\pm$ 0.00	0.46	0.46	0.31	0.53 $\pm$ 0.02
Prediction MAE	9.49 $\pm$ 0.02	9.21	9.14	7.64	7.63 $\pm$ 0.25