Table 2.
Ventilator free days (primary clinical effectiveness outcome) and composite fidelity score (primary implementation outcome) detectable differences.
| Ventilator free days (VFDs) (Primary Clinical Effectiveness Outcome) | |||||||
|---|---|---|---|---|---|---|---|
| Cohort | Population | Baseline mean VFDs | SD | Total # of measurements | ICC | Power (%) | Detectable Difference in mean VFDs |
| All MV patients | Primary | 21 | 10 | 18816 | 0.15 | 90 | 0.9 |
| Sustained HRF patients | Subgroup | 15 | 11 | 4928 | 0.02 | 90 | 2.1 |
| ARDS definition 1 patients | Subgroup | 15 | 11 | 4032 | 0.02 | 90 | 2.3 |
| ARDS definition 2 patients | Subgroup | 15 | 10 | 1792 | 0.02 | 90 | 3.0 |
| Sustained ARDS (Calgary) |
Subgroup |
11 |
10 |
2688 |
0.01 |
90 |
2.4 |
| Composite Fidelity Score (CFS) (Primary Implementation Outcome) | |||||||
| Cohort |
Population |
Baseline mean CFS (%) |
SD |
Total # of measurements |
ICC |
Power (%) |
Detectable Difference in mean CFS (%) |
| All MV patients | Primary | 20 | 32 | 18816 | 0.31 | 90 | 2.6 |
| Sustained HRF patients | Subgroup | 35 | 29 | 4928 | 0.32 | 90 | 4.6 |
| ARDS definition 1 patients | Subgroup | 36 | 30 | 4032 | 0.33 | 90 | 5.2 |
| ARDS definition 2 patients | Subgroup | 38 | 30 | 1792 | 0.38 | 90 | 7.4 |
| Sustained ARDS (Calgary) | Subgroup | 56 | 29 | 2688 | 0.02 | 90 | 7.1 |
ARDS = acute respiratory distress syndrome. CFS = composite fidelity score. ICC = intraclass correlation coefficient. HRF = hypoxemic respiratory failure. MV = mechanically ventilated. SD = standard deviation. VFDs = ventilator free days. Calculations for all MV patients, sustained HRF patients, ARDS definition 1 patients, and ARDS definition 2 patients are based on eCritical registry data from November 2018 to November 2019. Calculations for the ARDS Calgary cohort is based on standardized screening for ARDS in four ICUs in Calgary. See Appendix S2, SAP Supplementary Table 1 for details on criteria for sustained HRF, ARDS definition 1 and 2, and sustained ARDS.