Table 2.
Effects on the scores of Gastrointestinal Symptom Rating Scale (GSRS)
| Abexol-treatment | Baseline | Week 2 | Week 4 | Week 6 | Week 8 | Changes (%) |
|---|---|---|---|---|---|---|
| Abdominal pain | ||||||
| Tablets | 0.5 ± 0.5 | 0.5 ± 0.5 | 0.1 ± 0.3** | 0.1 ± 0.4** | 0.1 ± 0.4** | −80.0 |
| Suspension | 0.8 ± 0.7 | 0.8 ± 0.7 | 0.1 ± 0.4** | 0.1 ± 0.3** | 0.1 ± 0.2** | −87.5 |
| Acidity/hearthburn | ||||||
| Tablets | 0.8 ± 0.7 | 0.8 ± 0.7 | 0.5 ± 0.6* | 0.3 ± 0.5** | 0.2 ± 0.5** | −75.0 |
| Suspension | 0.8 ± 0.8 | 0.8 ± 0.8 | 0.3 ± 0.5* | 0.2 ± 0.4** | 0.2 ± 0.4** | −75.0 |
| Acid regurgitation | ||||||
| Tablets | 0.9 ± 0.7 | 0.9 ± 0.8 | 0.3 ± 0.5* | 0.1 ± 0.4** | 0.0 ± 0.2** | −100.0 |
| Suspension | 0.6 ± 0.8 | 0.6 ± 0.8 | 0.1 ± 0.3* | 0.1 ± 0.3** | 0.1 ± 0.2** | −83.3 |
| Sensation of stomach emptiness | ||||||
| Tablets | 0.8 ± 0.7 | 0.8 ± 0.7 | 0.4 ± 0.5* | 0.2 ± 0.4** | 0.1 ± 0.3** | −87.5 |
| Suspension | 0.7 ± 0.7 | 0.7 ± 0.7 | 0.3 ± 0.5* | 0.2 ± 0.4** | 0.1 ± 0.3** | −85.7 |
| Nauseas & vomits | ||||||
| Tablets | 0.3 ± 0.5 | 0.4 ± 0.5 | 0.0 ± 0.2** | 0.0 ± 0.2** | 0.0 ± 0.2** | −100.0 |
| Suspension | 0.3 ± 0.5 | 0.3 ± 0.5 | 0.1 ± 0.2** | 0.1 ± 0.2** | 0.1 ± 0.2* | −66.7 |
| Abdominal noises | ||||||
| Tablets | 0.8 ± 0.6 | 0.8 ± 0.6 | 0.3 ± 0.5* | 0.1 ± 0.4** | 0.1 ± 0.4** | −87.5 |
| Suspension | 0.6 ± 0.6 | 0.6 ± 0.6 | 0.2 ± 0.4* | 0.1 ± 0.4** | 0.1 ± 0.2** | −83.3 |
| Abdominal bloating | ||||||
| Tablets | 0.8 ± 0.7 | 0.8 ± 0.7 | 0.2 ± 0.4* | 0.1 ± 0.3** | 0.1 ± 0.3** | −87.5 |
| Suspension | 0.8 ± 0.8 | 0.8 ± 0.8 | 0.2 ± 0.4* | 0.1 ± 0.3** | 0.1 ± 0.3** | −87.5 |
| Eructation | ||||||
| Tablets | 0.9 ± 0.7 | 0.9 ± 0.7 | 0.6 ± 0.5* | 0.4 ± 0.5** | 0.3 ± 0.5** | −66.7 |
| Suspension | 0.6 ± 0.6 | 0.6 ± 0.6 | 0.4 ± 0.5* | 0.2 ± 0.4** | 0.2 ± 0.4** | −66.7 |
| Flatulence | ||||||
| Tablets | 1.0 ± 0.7 | 1.0 ± 0.7 | 0.5 ± 0.5* | 0.4 ± 0.5** | 0.4 ± 0.5** | −60.0 |
| Suspension | 0.8 ± 0.7 | 0.8 ± 0.7 | 0.4 ± 0.5* | 0.3 ± 0.5** | 0.3 ± 0.5** | −62.5 |
| Slow intestinal transit | ||||||
| Tablets | 0.3 ± 0.6 | 0.3 ± 0.6 | 0.2 ± 0.5 | 0.2 ± 0.4 | 0.1 ± 0.4** | −66.7 |
| Suspension | 0.2 ± 0.5 | 0.2 ± 0.5 | 0.1 ± 0.2 | 0.1 ± 0.3 | 0.1 ± 0.2 | −50.0 |
| Accelerated intestinal transit | ||||||
| Tablets | 0.2± 0.6 | 0.2 ± 0.6 | 0.1 ± 0.4 | 0.1 ± 0.3* | 0.1 ± 0.3* | −50.0 |
| Suspension | 0.1 ± 0.4 | 0.1 ± 0.4 | 0.1 ± 0.3 | 0.1 ± 0.2 | 0.0 ± 0.2* | −100.0 |
| Soft feces | ||||||
| Tablets | 0.4 ± 0.7 | 0.4 ± 0.7 | 0.2 ± 0.4 | 0.2 ± 0.4 | 0.1 ± 0.4* | −75.0 |
| Suspension | 0.3 ± 0.5 | 0.3 ± 0.5 | 0.2 ± 0.4 | 0.1 ± 0.2 | 0.0 ± 0.1* | −100.0 |
| Hard feces | ||||||
| Tablets | 0.3 ± 0.6 | 0.3 ± 0.6 | 0.1 ± 0.3 | 0.1 ± 0.4 | 0.0 ± 0.2* | −100.0 |
| Suspension | 0.1 ± 0.3 | 0.1 ± 0.3 | 0.1 ± 0.3 | 0.0 ± 0.3 | 0.1 ± 0.3 | 0.0 |
| Urgency for defecation | ||||||
| Tablets | 0.1 ± 0.4 | 0.2 ± 0.4 | 0.1 ± 0.4 | 0.1 ± 0.3 | 0.1 ± 0.2 | 0.0 |
| Suspension | 0.1 ± 0.3 | 0.1 ± 0.3 | 0.0 ± 0.2 | 0.0 ± 0.1 | 0.0 ± 0.1 | −100.0 |
| Sensation of incomplete emptiness | ||||||
| Tablets | 0.4 ± 0.5 | 0.3 ± 0.5 | 0.1 ± 0.2** | 0.0 ± 0.2** | 0.1 ± 0.2** | −75.0 |
| Suspension | 0.8 ± 0.8 | 0.8 ± 0.8 | 0.2 ± 0.4** | 0.1 ± 0.3** | 0.1 ± 0.3** | −87.5 |
| Whole score | ||||||
| Tablets | 8.6 ± 3.3 | 8.6 ± 3.3 | 3.6 ± 2.5** | 2.5 ± 1.8** | 1.9 ± 2.7** | −77.9 |
| Suspension | 7.0 ± 3.6 | 6.9 ± 3.6 | 2.8 ± 1.9** | 1.7 ± 1.4** | 1.3 ± 1.2** | −81.4 |
Values are presented as mean ± standard deviation.
*
p < 0.0125,
**
p < 0.001 comparison with baseline (Student test, Bonferroni adjustment).