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. Author manuscript; available in PMC: 2024 Jan 16.
Published in final edited form as: Science. 2022 Nov 24;378(6622):899–904. doi: 10.1126/science.abm0271

Fig. 1. 20-HA mRNA-LNP vaccine elicits long-lived antibody responses that react to all 20 HAs.

Fig. 1.

(A) Mice were simultaneously vaccinated i.m. with 20 different HA mRNA-LNPs (a combined total dose of 50 μg mRNA-LNP including 2.5 μg of each individual HA mRNA-LNP). Other groups of mice were vaccinated i.m. with 50 μg of H1 mRNA-LNP (B), 50 μg of H3 mRNA-LNP (C), 50 μg of IBV HA mRNA-LNP (D), or PBS (E). Sera were collected 28 days (A to E) or 118 days (F) later and antibody reactivity to different HAs were quantified using ELISAs coated with recombinant proteins. Seven or eight mice were included for each experimental group and in some instances data points overlap. Group 1 HAs are shown in blue and group 2 HAs are shown in red. AUC; area under the curve. Data are representative of two independent experiments and are shown as mean ± SEM. Raw ELISA data curves are shown in fig S2.