Figure 1.

Frequency of resistance-conferring mutations for all first-line antituberculosis drugs

Drug-resistant conferring variants identified by WGS in the dataset are classified depending on their association with resistance to isoniazid (A), rifampicin (B), ethambutol (C), and pyrazinamide (D). Variants strongly associated with drug resistance and variants supported by less evidence according to WHO are indicated. It is also indicated whether the mutation is present in a phenotypically resistant isolate or a susceptible isolate. SNP=single-nucleotide polymorphism. WGS=whole-genome sequencing.